|
KMID : 0613820070170060816
|
|
Journal of Life Science
2007 Volume.17 No. 6 p.816 ~ p.821
|
|
|
Inhibition of Melanin Synthesis by Mycelial Culture Broth of Paecilomyces japonica in the Mulberry Leaf Extract
|
|
Park Sang-Sang
Ryu Young-Bae
Lee Young-Hoon
Cho Yong-Un
Cho Soo-Jeong
Choi Young-Ju
Park Ki-Hoon
Gal Sang-Wan
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the whitening effect of mycelial culture broth of P. japonica in the mulberry leaf extract. The culture broth inhibited melanin synthesis in vitro in the concentration dependent manner of 10 to 50%. The mulberry leaf extract itself has a cytotoxicity to the mouse melanoma cell, B16BL6 with the value of IC50 of 7% concentration. But the culture broth of P. japonica in the mulberry leaf extract did not show any cytotoxicity up to 50%. Therefore, we concluded the mycelial culture broth of P. japonica in the extract of mulberry leaf can be used as a whitening cosmetic resource.
|
|
|
KEYWORD
|
|
|
Paecilomyces japonica, Mulberry leaf, Melanin, Tyrosinase inhibitor, B16BL6
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|